B2B marketplace · Technology-grade grown diamond
B2B marketplace · Technology-grade grown diamond
Non-toxic nanodiamonds for bio-imaging, targeted drug delivery and long-term cell tracking.
01
In advanced medicine and life sciences, nanometer-scale synthetic diamonds (4–100 nm) are deployed as non-toxic bio-imaging agents, targeted drug delivery carriers, fluorescent cellular biomarkers, and bio-compatible surface coatings for medical implants. Fluorescent Nanodiamonds (FNDs) containing Nitrogen-Vacancy (NV) color centers are internalized by targeted cells, enabling long-term, high-resolution optical tracking and intracellular sensing without photobleaching. Concurrently, functionalized Detonation Nanodiamonds (DNDs) act as therapeutic delivery vehicles by chemically binding chemotherapy agents, gene therapies, or proteins, delivering them directly to targeted tumors or diseased tissue while shielding surrounding healthy tissue.
02
Nanodiamonds solve the critical limitations of conventional biomedical nanoparticles—such as severe cellular toxicity, rapid photobleaching, and chemical instability. Formed entirely of carbon, nanodiamonds exhibit exceptional bio-compatibility, low cytotoxicity, and high systemic tolerance within living organisms. Unlike organic fluorescent dyes or semiconductor quantum dots, FNDs offer infinite photostability under continuous laser excitation and zero blinking, enabling uninterrupted real-time tracking of cellular processes over days or weeks. Furthermore, nanodiamonds feature an exceptionally high surface-area-to-volume ratio, allowing dense drug loading and versatile surface functionalization (carboxyl, hydroxyl, or amine termination) to bind specific targeting ligands or antibodies.
03
Biomedical applications utilize two main categories of tech-grade nanodiamonds: Fluorescent Nanodiamonds (FNDs) and high-purity Detonation Nanodiamonds (DNDs). FNDs (typically 10 to 100 nm, produced from HPHT or CVD diamond milling) are engineered with high NV center concentrations (> 1 ppm) to yield bright red/near-infrared emission (600–750 nm) that easily penetrates biological tissue. DNDs (typically 4–5 nm primary particle size, produced via controlled detonation) feature uniform spherical morphologies and high surface area (> 300 m2/g). Both types require rigorous chemical purification to remove non-diamond graphite and heavy metal residues, along with specialized bioconjugation (e.g., surface functionalization with streptavidin, biotin, or specific targeting proteins) to prevent bio-aggregation in physiological saline solutions.
Key figure
4–100 nm
Particle sizes for imaging and drug delivery
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